Hyperuricemia Secondary to Chemotherapy FAQ
What causes hyperuricemia after chemotherapy?
Rapid cancer cell death releases purines, increasing uric acid production.
Is hyperuricemia a common chemotherapy side effect?
Yes, especially in treatments for lymphomas and leukemias.
How is chemotherapy-induced hyperuricemia diagnosed?
Through blood tests measuring serum uric acid levels.
What are the risks of untreated hyperuricemia?
Kidney injury, gout attacks, and potentially fatal acute kidney failure.
When does hyperuricemia typically occur post-chemotherapy?
Usually within 24-48 hours after treatment initiation.
How does rasburicase treat hyperuricemia?
Breaks down uric acid into allantoin, which is easier to excrete.
Are there dietary restrictions for hyperuricemia patients?
Reducing purine-rich foods (e.g., organ meats, seafood) may help.
Can hyperuricemia cause gout during chemotherapy?
Yes, elevated uric acid levels can trigger gout flares.
Is allopurinol suitable for all chemotherapy patients?
No, contraindicated in severe kidney dysfunction or hypersensitivity.
How long is hyperuricemia treatment typically needed?
Varies; often continued until uric acid levels stabilize post-chemotherapy.
Does febuxostat require dose adjustments?
Yes, based on kidney function and uric acid response.
Can hyperuricemia lead to chemotherapy dose reduction?
Possibly, if kidney function is compromised.
Are there alternative treatments for rasburicase intolerance?
Yes, allopurinol or febuxostat may be used.
How often are uric acid levels monitored?
Frequently during and after chemotherapy, as per clinical guidelines.
Is hyperuricemia management covered by Malaysian health insurance?
Typically, yes, for chemotherapy-related complications.
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