Cytomegalovirus Prophylaxis FAQ
What is CMV prophylaxis?
Preventive antiviral therapy to reduce CMV infection risk in immunocompromised individuals.
Who needs CMV prophylaxis?
Primarily organ transplant recipients and HIV patients with low CD4 counts.
How long does CMV prophylaxis last?
Typically 3-6 months, depending on individual risk factors and guidelines.
What medications are used for CMV prophylaxis?
Commonly valganciclovir, ganciclovir, or aciclovir, based on patient condition.
Is CMV prophylaxis necessary for all transplant patients?
Not always; it depends on donor-recipient CMV serostatus and immunosuppression level.
Can CMV prophylaxis cause side effects?
Yes, potential side effects include kidney dysfunction and bone marrow suppression.
How is CMV prophylaxis monitored?
Through regular blood tests to assess drug levels and CMV viral load.
What if CMV prophylaxis fails?
Treatment may switch to second-line antivirals or involve combination therapy.
Is CMV prophylaxis covered in Malaysia's healthcare?
Yes, under the National Pharmaceutical Services Programme for eligible patients.
Can I stop CMV prophylaxis abruptly?
No, it should be tapered or discontinued per medical guidance to avoid resistance.
Are there drug interactions with CMV prophylaxis?
Yes, particularly with immunosuppressants; dose adjustments may be needed.
How does CMV prophylaxis affect pregnancy?
Requires careful risk-benefit assessment due to potential fetal harm.
Is vaccination available for CMV prophylaxis?
Currently, no licensed CMV vaccine; prophylaxis relies on antivirals.
What lifestyle changes aid CMV prophylaxis?
Avoiding close contact with infected individuals and practicing good hygiene.
How is CMV diagnosed during prophylaxis?
Through PCR testing for viral DNA in blood or tissue samples.
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