Linezolid is an oxazolidinone-class antibiotic used to treat severe bacterial infections, including MRSA and VRE, by inhibiting protein synthesis in bacteria. It is typically administered orally or intravenously.

Linezolid FAQ


What is Linezolid used for?

Linezolid treats severe bacterial infections like MRSA and VRE, especially when other antibiotics are ineffective.

How does Linezolid work?

It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, disrupting protein formation.

What are common side effects of Linezolid?

Nausea, vomiting, diarrhea, and headache are common; serious side effects include nerve damage with prolonged use.

How is Linezolid administered?

It can be given orally (tablets, suspension) or intravenously, typically every 12 hours.

What infections does Linezolid target?

It's effective against Gram-positive bacteria, including MRSA, VRE, and some Streptococcus and Enterococcus species.

Can Linezolid be used in children?

Yes, but dosage is weight-based and requires careful monitoring by a pediatrician.

How long is a typical Linezolid treatment course?

Duration varies by infection severity but usually ranges from 7 to 14 days.

Does Linezolid require a prescription?

Yes, it's a prescription-only medication due to its potency and potential side effects.

Can Linezolid interact with other medications?

Yes, it can interact with MAO inhibitors, serotonin reuptake inhibitors, and certain antidepressants.

Is Linezolid safe during pregnancy?

Use in pregnancy is generally avoided unless benefits outweigh risks; consult a healthcare provider.

What if I miss a dose of Linezolid?

Take the missed dose as soon as remembered, but skip if almost time for the next dose.

How should Linezolid be stored?

Store at room temperature, away from moisture and heat, and keep out of reach of children.

Can Linezolid cause allergic reactions?

Yes, though rare; signs include rash, itching, or difficulty breathing; seek medical help if experienced.

Is Linezolid effective against all bacteria?

No, it's specifically effective against certain Gram-positive bacteria and not broadly spectrum.

What lifestyle adjustments are needed while on Linezolid?

Avoid certain foods (e.g., aged cheeses) and activities that may increase fall risk due to potential dizziness.

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